GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2273 | 1 | rs4859413 | chr4:76898250 | NAAA | chr4:76831809-76862166:- | 0.36 | 7.17 | 2.8E-12 | Longevity |
| THCA | cis | rs2273 | 1 | rs4859581 | chr4:76906974 | NAAA | chr4:76831809-76862166:- | -0.35 | -7.04 | 6.71E-12 | Longevity |
| THCA | cis | rs2273 | 1 | rs4859582 | chr4:76907213 | NAAA | chr4:76831809-76862166:- | -0.35 | -7.04 | 6.71E-12 | Longevity |
| THCA | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | CCDC111 | chr4:185570767-185616112:+ | -0.31 | -7.31 | 1.1E-12 | Kawasaki disease |
| THCA | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | MLF1IP | chr4:185615220-185655286:- | 0.47 | 10.79 | 1.91E-24 | Kawasaki disease |
| THCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | ADAL | chr15:43622872-43646094:+ | -0.49 | -11.39 | 8.93E-27 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | CATSPER2 | chr15:43922774-43959900:- | -0.26 | -4.72 | 3.16E-6 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | STRC | chr15:43891762-43924561:- | 0.32 | 5.96 | 4.8E-9 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | TUBGCP4 | chr15:43663313-43698238:+ | 0.12 | 3.52 | 0.000465 | Tumor biomarkers |
| THCA | cis | rs11734488 | 1 | rs4863772 | chr4:139120683 | SLC7A11 | chr4:139085248-139163503:- | -0.22 | -4.47 | 9.67E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs2412488 | 1 | rs4864759 | chr4:54259408 | SCFD2 | chr4:53739152-54232242:- | 0.2 | 3.85 | 0.000132 | DNA methylation (variation) |
| THCA | cis | rs6832769 | 1 | rs4864998 | chr4:56332606 | TMEM165 | chr4:56262090-56292342:+ | -0.14 | -3.55 | 0.000427 | Personality dimensions |
| THCA | cis | rs6832769 | 1 | rs4865008 | chr4:56410855 | TMEM165 | chr4:56262090-56292342:+ | 0.15 | 3.65 | 0.000296 | Personality dimensions |
| THCA | cis | rs6832769 | 1 | rs4865010 | chr4:56414962 | TMEM165 | chr4:56262090-56292342:+ | 0.14 | 3.64 | 0.000306 | Personality dimensions |
| THCA | cis | rs4869313 | 1 | rs4869313 | chr5:96223880 | ERAP2 | chr5:96211644-96255398:+ | -1.11 | -35.76 | 3.5E-137 | Pediatric autoimmune diseases |